THH..TetrahydroHarmine

[senorsalvia]

As most will know, THH is a minor constituent in many of the MAO powerplants such as Caapi..Recently I've noted on a few other entheo boards that researchers are finding pleasant healing sessions from sublingual doses in the 30-50mg range from this often discounted substance.. Bioassay reports indicate greatly reduced nausea when used as one would do with Harmala or Harmine... Might be worth a look see...

[Anonymous]

It's awesome.

//http://www.dmt-nexus.com/forum/default.aspx?g=posts&t=2265

[Amomynous]

As most will know, THH is a minor constituent in many of the MAO powerplants such as Caapi..

Actually, if you look at the data THH is a pretty large constituent of caapi, sometimes almost as much THH as harmine, or at least in the same ball-park:

The concentrations of alkaloids in the ayahuasca beverages are, not surprisingly, several times greater than in the source plants from which they are prepared. Based on a quantitative analysis of the major alkaloids in several samples of ayahuasca collected on the upper Rio Puris rivier & Lindgren (1972) calculated that a 200 ml dose of ayahuasca contained an average of 30 mg of harmine, 10 mg tetrahydroharmine, and 25 mg DMT. Callaway, et al., determined the following concentrations of alkaloids in the hoasca tea utilized in the biomedical study with the UDV (mg/ml): DMT, 0.24; THH, 1.07; harmaline, 0.20; and harmine 1.70. A typical 100 ml dose of hoasca thus contains in mg: DMT, 24; THH, 107; harmaline, 20; harmine, 170.  Interestingly, these concentrations are above the threshold of activity for i.v. administration of DMT (Strassman & Qualls, 1994).

(From The Scientific Investigation of Ayahuasca: A Review of Past and Current Research, The Heffter Review of Psychedelic Research, Volume 1, 1998, McKenna, Callaway, Grob)

THH has week activity in modulating serotonin reuptake, and thus is considered to be psychoactive. However, I wouldn't expect any great "entheogenic" activity. Its magic, I believe, is in modulating the effects of harmine in a traditional tea. I believe that's why people report such a subjective difference between ayahuasca and its analogs; THH is pretty much absent in the analog plants.

[Anonymous]

y'all really should check this out.

PM me for a vendor of pure THH.

[Amomynous]

y'all really should check this out.

PM me for a vendor of pure THH.

In what way is the purified alkaloid better than a broad-spectrum extraction?

Remeber, the magic is in the mix.

[suicybe]

a friend has taken 25 rectally with great results, minus the burning he says, which only lasts 5 min
a friend took 300 orally no results
another friend took 125 orally with decent results
another friend took 50 mg sublingually with mild results

my conclusion is that THH is an admixture chemical and should be put with other alkaloids (harmine/harmaline) in conjunction with the light (dmt)

its been discussed about the absense of THH in pharmahausca and is often agreed upon that it is the guiding spirit per say, in compound.
though nothing out of context is what it really should be, so THH should, IMHO, be taken with the rest of the holy give me brew


another friend may try 50 mg rectally
report to come...

[Eva]

I have been a very long time reader here, finally registered. Nice to meet you all finally. Just as Amomynous mentions above, The Callaway study that showed 170mg harmine and 110mg thh is one of the best studies out there.

Had used THH for several years back when it was available from FV (flowing visions), it is one of the strongest
healing components in caapi, about the only place you can still get a full spectrum caapi extract with very good
levels of tetrahydroharmine is if you go to ecrater.com and search for "caapi extract". There is a place there that carries a 280mg caapi extract that has about 130mg of THH in it, along with harmine and harmaline. I think it was sacred forest botanicals, had lab reports posted of the extract confirming it had THH.

In the Heffter Institute study by Callaway (1) he found 170mg of harmine and 110mg of THH in a typical brew and small amount of harmaline (typically 10% of harmine level) used bi-weekly by the UDV. In (2) below, 32 variety of caapi were analyzed for various alkaloid levels. In (3) below, we see that 170mg harmine found in the UDV brew is a highly activating dose for admixture plants.

(1) Here was the reported levels of harmine, thh, and harmaline from UDV brew study (pg 2 of 12):
"Scientific Investigation of Ayahuasca: A Review of Past & Current Research"
by Mckenna, Ph.D, Callaway, Ph.D, Grog, M.D.
http://www.heffter.org/docs/hrireview/01/chapter10.pdf

(2) Here was the method Callaway used for testing, (pg 2 of 6):
"Phytochemical Analyses of Banisteriopsis Caapi and Psychotria Viridis"
by Callaway, Ph.D., Brito, M.D., Neves, M.D.
http://www.vetmed.helsinki.fi/abs/dokum ... plants.pdf 

    High pressure liquid chromatography (HPLC) with fluorescence
    detection . The chromatographic column packed with c-8 material
    and the mobile phase has 20% methanol, 20% acetonitrile and 60%
    0.1m ammonium acetate buffer, adjusted to ph 6.9 with acetic acid.
    Individual signals in the chromatogram were verified according
    to retention time and molecular weight by liquid chromatographic mass
    spec (LC-MS) using a VG thermospray-plasma probe coupled to a
    VG TRio-2 quadrople mass spec.

I would imagine modern methods of GC/MS testing are much improved over Callaway's day, technology is always advancing.

(3) Moderate and Strong activating amounts of harmine (pg 250 of 639):
"Pharmacotheon: Entheogenic drugs, their plant sources & history"
by Jonathan Ott.

For EXPERIMENT 12, I increased the qty of harmine base to 120mg, and ingested this along with 35mg DMT free-base. By 45 minutes after ingestion,it was obvious the dose was psychoptic, and I experienced a distinct DMT effect building to a peak at 1:05 after ingestion and maintaining a plateau until 1:50, with the effects largely dissipated by 3 hours after ingestion. This experience was of comparable intensity to EXPERIMENT 6 involving ingestion of a similar amount of DMT (30mg; 0.38mg/kg) with extract of 4g of harmel seeds, and we may conclude that 120mg of harmine (1.5mg/kg) will effect sufficient in vivo MAO-inhibition to render DMT active orally with a longer duration and about half the potency of inhaled DMT vapor.

To confirm these results, I decided to make another experiment with the harmine/DMT combinations, slightly increasing the amounts of both compounds.Accordingly, I prepared a capsule containing 160mg of harmine base; (2.0mg/kg) and 40mg DMT base (0.5mg/kg).

This capsule of 160mg harmine base and 40mg DMT base was ingested in EXPERIMENT 13 and indeed provoked a proportionally stronger DMT effect with the first effects felt in 20 minutes, building to a peak by 1:30 after ingestion with a plateau until 2:40, and clearly diminishing effects at 3:00 after ingestion. By 4:00 after ingestion there were no effects, nor after-effects. All in all, the experience was quite pleasant and similar to EXPERIMENT 3 in Ecuador with about 50 leaves of DMT-containing Psychotria viridis per dose.

Harmaline is about twice as potent as harmine.

[Eva]

Role of THH in caapi vine:

Rue contains less than 1% tetrahydroharmine. It plays no role in rue. It is only found in very significant concentrations in caapi.

It is the 2nd highest concentrated alkaloid found in caapi, right behind harmine, in some variety of caapi it is found in the same concentration as harmine. But in most variety, it is found in slightly less concentrations then harmine.

1) one of the strongest healing components in caapi, found to help stop drug abuse & violent behaviors, also up-regulates serotonin receptor sites, a very positive benefit, which stimulates the growth of new receptors. (Callaway)

2) doubles the half-life of admixture plant before it gets "zapped" by mitrochondria in the brain, allowing the experience to last longer. (theorized by D.Mckenna)

2) shuts down serotonin signalling (agonist) at the brain's 5-HT1a receptors, which make up more than 80% of all brain 5-ht receptors, this allows "real ayahuasca visions to be made possible" All the other natural oral entheogens do the same thing at the brain's 5-HT1a sites. (Nichols)

3) greatly reduces fear when taking ayahuasca (subjective experience)

4) increases focus and concentration, while decreasing confusion (subjective exp)

5) higher frequency vibration felt thru body (subjective exp)

6) increased appreciation of music, art, beauty & all things spiritual (subjective exp)

7) afterglow which lasts for a day or more (subjective experience)

8. has no abuse potential (subjective experience)

9) induces a strong tolerance of many weeks (subjective experience)

10) known as "the force" by shamans, vines high in THH are highly prized by them (Metzner)
     

[Eva]

Also, subjectively, THH appeared to have some sort of visual 5-Ht2A or possibly adrenal agonism in order to balance out it's 5-ht1a agonism. How else to explain the glowing colors, sparkle & sacred look to everything? Recall that 5-ht1a agonism is inhibitory, while both 5-ht2a and adrenal agonism is stimulatory, yin and yang, so no matter what dosage of thh, it's effects were always balanced in full, nature is ingenious. It's too bad Thh was never analyzed for it's full complete receptor activity, I'm sure if it would have been, it would have come up a treasure trove of activity, see below for more:

The Receptorome project by Thomas S. Ray:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009019
hxxp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009019

[Eva]

Contrary to popular belief, THH is not an maoi, it serves an entirely different purpose in the plant.

[Eva]

 If you google "pure alkaloid caapi extract" you will find there are two different kinds of extracts, one is the caapi bark extract and the other is the caapi leaf extract. 

[Eva]

"Various alkaloid profiles in decoctions of Banisteriopsis caapi"

Callaway, James C. (June 2005)

http://catbull.com/alamut/Bibliothek/various%20alkaloid%20profiles%20in%20aya%20decoction.pdf

In the study above (see page 2) notice how some samples had more THH (tetrahydroharmine) than harmine, others more harmine than THH. To avoid nausea and purging, swim has seen "pure alkaloid caapi extracts", they are out there if you google them.

[Stonehenge]

If you google "pure alkaloid caapi extract" you will find there are two different kinds of extracts, one is the caapi bark extract and the other is the caapi leaf extract. 

The caapi vine itself is used more so than the bark.

[Eva]

Thanks for the correction Stonehenge, I meant to say vine instead of bark, much appreciated.

[Eva]

The Siona make a distinction among the following culivated forms: wai yahe (flesh yahe, with green leaves), ya wi yahe (pekari yahe, with yellow-striped leaves), naso anya yahe (monkey snake yahe), naso yahe (monkey yahe, with striped leaves), yahe repa (proper yahe), tara yahe (bone yahe, with knotty stems), airo yahe (forest yahe),  bi a yahe (bird yahe, with small leaves), sia sewi yahe (egg sewi yahe, with yellowish leaves), sese yahe (white-lipped peccary yahe), weki yahe (tapir yahe, of large size), yai yahe (jaguar yahe), nea yahe (black yahe, with dark stems), horo yahe (flower yahe), and sise yahe.