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an MAOI related concern i'd like some input on...

Started by newgrower, December 10, 2006, 12:58:53 PM

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laughingwillow

#15
I'm guessing the addition of M hostilis rootbark to the rue tea was the cause for concern of serotonin syndrome in the initial post.

lw
Lost my boots in transit, babe,
smokin\' pile of leather.
Nailed a retread to my feet
and prayed for better weather...

blizznshot

#16
^^^^
Why would you associate the MHRB with serotonin syndrome?  Just so we're on the same page, this substance is a source of dimethy tryptamine.  Conversely, it is the MAOI portion (Syrian Rue in this case) that is normally associated with SS, as inhibition of MAO leads to an increased life (and hence higher concentration) of synaptic serotonin.  

Although some of the effects of DMT are attributed to a serotonergic action, I am unaware of this compound inducing SS when combined with an otherwise benign dosage of MAOI.