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Wow..I can not thank you enough for all that information.  I truly appreciate your time. I am sure it has been asked many times.  Soooooo...I guess I am kind of screwed if I take acid.  I can TRY again...I will not use the Xanax.  I fear it will not be enough to get my trip back.  You are insanely educated in this area.....I am not so great at chemistry.  It is so sad for me though.  There is nothing else I can really do to change it.  dammit!..THANK YOU...any more suggestions are gladly accepted....I knw your time is precious...I thank you for it.
m

Hello everyone!.  I am here to ask for help and advice.  In the past..like 15 years ago, I was able to enjoy psychedelics.  In the last few years...after a long hiatus I tried them again.  To my shock, nothing happened.  I have tried several times to use acid and mushrooms with  no effect.  I know what I am getting is good, so I am at a loss.
Here is what I know.  I am on medications.  I also get migraines.  I FEEL like it is the Beta Blocker that might be the issue. 
I would like to list my meds and hope someone can help me figure it out. 
1.    CYMBALTA[/size][size=0px]®[/size][/color] (duloxetine delayed-release capsules) is a selective [/font][/color][/size]serotonin[/size] and [/size]norepinephrine[/size] [/size]reuptake[/size] inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C[/size][size=0px]18[/size][/color]H[/font][/color][/size][size=0px]19[/size][/color]NOS•HCl, which corresponds to a molecular weight of 333.88[/font][/color]
[/size]https://www.rxlist.com/cymbalta-drug.htm#description[/size]



2,  Metroproplol or Lopressor..It is a Beta Blocker,,.I take for a preventative for my migraines.  I do not have high blood pressure. 
[/size]metoprolol[/b][/color][/size] succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended-release tablets.[/size] TOPROL-XL has been formulated to provide a controlled and predictable release of [/size]metoprolol[/b][/color][/size] for once-daily ..
https://medlineplus.gov/druginfo/meds/a682864.html



3.  RELPAX..to abort a migraine. 




Relpax[/b] (eletriptan hydrobromide) is a selective serotonin receptor agonist used to treat migraine headaches. ... Tell your doctor if you have serious side effects of [/color]Relpax including: ... Our [/color]Relpax Side Effects Drug Center provides a comprehensive view of available drug information on the ...I do not think this is the problem as I have always tried not to take it when I try Psychedelics. 
[/color]https://medlineplus.gov/druginfo/meds/a682864.html[/font]



4. CELEBREX  This medication is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. ... If you are treating a chronic condition such as arthritis ..
Again..I do not think this is the problem either. 


5,  Xanax...After reading a bit...it seems that this WILL kill a trip...is this my problem??  On the days I tried to trip I am SURE I took a few mg of Xanax...is that it??


would any of these also kill mushrooms?  I am kind of upset about it all...
Any help would be so appreciated...
Grateful for you all..
m