Found this pretty interesting but didn't know were to post it.... maybe a new news forum?
//http://www.sciencemag.org/cgi/content/abstract/323/5916/934
The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
Dominique Fontanilla,1 Molly Johannessen,2 Abdol R. Hajipour,3 Nicholas V. Cozzi,1 Meyer B. Jackson,2 Arnold E. Ruoho1*
The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor. The sigma-1 receptor pharmacophore includes an alkylamine core, also found in the endogenous compound N,N-dimethyltryptamine (DMT). DMT acts as a hallucinogen, but its receptor target has been unclear. DMT bound to sigma-1 receptors and inhibited voltage-gated sodium ion (Na+) channels in both native cardiac myocytes and heterologous cells that express sigma-1 receptors. DMT induced hypermobility in wild-type mice but not in sigma-1 receptor knockout mice. These biochemical, physiological, and behavioral experiments indicate that DMT is an endogenous agonist for the sigma-1 receptor.
1 Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
2 Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
3 Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran.
Interesting. Thank you for posting it.
Quote from: "kemp"The sigma-1 receptor is widely distributed in the central nervous system and periphery............it is currently considered an orphan receptor.
Now that is interesting. Thanks Kemp. And here I was thinking it was just a waste product of seratonin.
DMT triggers the Pineal Gland, I just learned from a trailer from the, not yet released; DMT; The Spirit Molecule by Rick Strassman. So when you dream you use a smal dosage of a DMT trip..I've never tried it but now I really want to, sometime when the time is right.
It's an old post so you've probably heard of it, but could'nt help myself when I saw it..