I'm trying to understand better.
Anyone experience Salvia while being hooked on opiates?
Ive come across this document Kappa Opioid Receptor Agonist (//http://www.unet.univie.ac.at/~a0001355/kappa/).
However I'm wondering how this reacts to opiod tolerated users. I experience Salvia and had a very physical experience where mosqitoe bites felt like needles through my entire body.
I thought most pain relieving opiates work on the mu-receptors so I wouldn't expect any cross tolerance or sensitivity of one on the other.
Salvia isn't going to mess with the opiates and the opiates are not going to mess with salvia experiences.
http://en.wikipedia.org/wiki/Opioid_rec ... d_receptor (http://en.wikipedia.org/wiki/Opioid_receptor#The_.CE.BC-opioid_receptor)
I have read posts from people on methadone, and they also say that it does not seem interfere with the Salvinorin A's effects.
Quote from: "winder"I thought most pain relieving opiates work on the mu-receptors so I wouldn't expect any cross tolerance or sensitivity of one on the other.
Salvia isn't going to mess with the opiates and the opiates are not going to mess with salvia experiences.
http://en.wikipedia.org/wiki/Opioid_rec ... d_receptor (http://en.wikipedia.org/wiki/Opioid_receptor#The_.CE.BC-opioid_receptor)
yea, Winder is correct, most opioids, such as morphine, codeine, hydrocodone, hydromorphone, fentanyl... work on mu receptors. However, some opioids such as nalbuphine, butorphanol and pentazocine (less common drugs) work as mu-antagonist AND KAPPA-agonists...they have both actions...
so...it's so tricky and I think research is warranted if you're wondering about the latter drugs I mentioned...
hope this helps...
-jg